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Journal of Biomedical Optics

Assessment of inflow and washout of indocyanine green in the adult human brain by monitoring of diffuse reflectance at large source-detector separation
Author(s): Adam Liebert; Piotr Sawosz; Daniel Milej; Michal Kacprzak; Marcin Botwicz; Roman Maniewski; Wojciech Weigl; Ewa Mayzner-Zawadzka; Joanna Maczewska; Katarzyna Fronczewska; Leszek Królicki
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Paper Abstract

Recently, it was shown in measurements carried out on humans that time-resolved near-infrared reflectometry and fluorescence spectroscopy may allow for discrimination of information originating directly from the brain avoiding influence of contaminating signals related to the perfusion of extracerebral tissues. We report on continuation of these studies, showing that the near-infrared light can be detected noninvasively on the surface of the tissue at large interoptode distance. A multichannel time-resolved optical monitoring system was constructed for measurements of diffuse reflectance in optically turbid medium at very large source-detector separation up to 9 cm. The instrument was applied during intravenous injection of indocyanine green and the distributions of times of flight of photons were successfully acquired showing inflow and washout of the dye in the tissue. Time courses of the statistical moments of distributions of times of flight of photons are presented and compared to the results obtained simultaneously at shorter source-detector separations (3, 4, and 5 cm). We show in a series of experiments carried out on physical phantom and healthy volunteers that the time-resolved data acquisition in combination with very large source-detector separation may allow one to improve depth selectivity of perfusion assessment in the brain.

Paper Details

Date Published: 1 April 2011
PDF: 8 pages
J. Biomed. Opt. 16(4) 046011 doi: 10.1117/1.3574018
Published in: Journal of Biomedical Optics Volume 16, Issue 4
Show Author Affiliations
Adam Liebert, Institute of Biocybernetics and Biomedical Engineering (Poland)
Piotr Sawosz, Institute of Biocybernetics and Biomedical Engineering (Poland)
Daniel Milej, Institute of Biocybernetics and Biomedical Engineering (Poland)
Michal Kacprzak, Institute of Biocybernetics and Biomedical Engineering (Poland)
Marcin Botwicz, Institute of Biocybernetics and Biomedical Engineering (Poland)
Roman Maniewski, Institute of Biocybernetics and Biomedical Engineering (Poland)
Wojciech Weigl, Medical Univ. of Warsaw (Poland)
Ewa Mayzner-Zawadzka, Medical Univ. of Warsaw (Poland)
Joanna Maczewska, Medical Univ. of Warsaw (Poland)
Katarzyna Fronczewska, Medical Univ. of Warsaw (Poland)
Leszek Królicki, Medical Univ. of Warsaw (Poland)


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