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Journal of Biomedical Optics • Open Access

Fiber loop ringdown DNA and bacteria sensors
Author(s): Chamini Herath; Chuji Wang; Malik Kaya; David Chevalier

Paper Abstract

We report a new type of refractive index-based biosensor using a fiber loop ringdown evanescent field (FLRD-EF) sensing scheme, in which the sensing signal is a time constant and detection sensitivity is enhanced by the multipass nature of the ringdown technique. Bulk index-based detections of three different single strand DNAs and one type of bacteria are demonstrated for the FLRD-EF sensors that utilize a partially-etched single mode fiber as the sensor head. Stepwise coating of the sensor head with poly-L-lysine and a probe DNA has enabled surface index-based label-free target DNA sensing. We expect an array of FLRD-EF biosensors to be created, which are superior to counterparts in terms of simplicity, low cost, and high sensitivity.

Paper Details

Date Published: 1 May 2011
PDF: 4 pages
J. Biomed. Opt. 16(5) 050501 doi: 10.1117/1.3572046
Published in: Journal of Biomedical Optics Volume 16, Issue 5
Show Author Affiliations
Chamini Herath, Mississippi State Univ. (United States)
Chuji Wang, Mississippi State Univ. (United States)
Malik Kaya, Mississippi State Univ. (United States)
David Chevalier, Mississippi State Univ. (United States)

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