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Journal of Biomedical Optics • Open Access

Endomicroscopy imaging of epithelial structures using tissue autofluorescence
Author(s): Bevin Lin; Dennis L. Matthews; Stavros G. Demos; Shiro Urayama; Ramez M. G. Saroufeem

Paper Abstract

We explore autofluorescence endomicroscopy as a potential tool for real-time visualization of epithelial tissue microstructure and organization in a clinical setting. The design parameters are explored using two experimental systems-an Olympus Medical Systems Corp. stand-alone clinical prototype probe, and a custom built bench-top rigid fiber conduit prototype. Both systems entail ultraviolet excitation at 266 nm and/or 325 nm using compact laser sources. Preliminary results using ex vivo animal and human tissue specimens suggest that this technology can be translated toward in vivo application to address the need for real-time histology.

Paper Details

Date Published: 1 April 2011
PDF: 8 pages
J. Biomed. Opt. 16(4) 046014 doi: 10.1117/1.3565216
Published in: Journal of Biomedical Optics Volume 16, Issue 4
Show Author Affiliations
Bevin Lin, UC Davis Medical Ctr. (United States)
Dennis L. Matthews, UC Davis Medical Ctr. (United States)
Stavros G. Demos, UC Davis Medical Ctr. (United States)
Shiro Urayama, UC Davis Health System (United States)
Ramez M. G. Saroufeem, UC Davis Health System (United States)

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