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Journal of Biomedical Optics • Open Access

Dynamic fluorescence imaging for multiparametric measurement of tumor vasculature
Author(s): Myunghwan Choi; Kyungsun Choi; Seung-Wook Ryu; Jungwhoi Lee; Chulhee Choi

Paper Abstract

Angiogenesis is essential for tumor growth and a promising target for cancer therapy. Blood vessel monitoring is an indispensable tool for evaluation and development of anti-angiogenic drugs. Here, we report a new noninvasive in vivo imaging tool, named dynamic fluorescence imaging (DyFI), for the simultaneous measurement of multiple vascular parameters including vascular density, perfusion rate, and permeability using spatiotemporal profiles of indocyanine green. Using DyFI in a tumor xenograft model, we quantitatively measured multiple vascular parameters in tumors and normal tissues with high spatial resolution. The multimodality of this method allowed us to find negative spatial correlations between perfusion and permeability. Moreover, DyFI was effective for revealing the early effects of an anti-angiogenic drug. We suggest that DyFI could be a useful tool for the preclinical development of anti-angiogenic drugs.

Paper Details

Date Published: 1 April 2011
PDF: 8 pages
J. Biomed. Opt. 16(4) 046008 doi: 10.1117/1.3562956
Published in: Journal of Biomedical Optics Volume 16, Issue 4
Show Author Affiliations
Myunghwan Choi, KAIST (Korea, Republic of)
Kyungsun Choi, KAIST (Korea, Republic of)
Seung-Wook Ryu, KAIST (Korea, Republic of)
Jungwhoi Lee, KAIST (Korea, Republic of)
Chulhee Choi, KAIST (Korea, Republic of)


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