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Journal of Biomedical Optics • Open Access

Resting-state functional connectivity assessed with two diffuse optical tomographic systems

Paper Abstract

Functional near-infrared spectroscopy (fNIRS) is recently utilized as a new approach to assess resting-state functional connectivity (RSFC) in the human brain. For any new technique or new methodology, it is necessary to be able to replicate similar experiments using different instruments in order to establish its liability and reproducibility. We apply two different diffuse optical tomographic (DOT) systems (i.e., DYNOT and CW5), with various probe arrangements to evaluate RSFC in the sensorimotor cortex by utilizing a previously published experimental protocol and seed-based correlation analysis. Our results exhibit similar spatial patterns and strengths in RSFC between the bilateral motor cortexes. The consistent observations are obtained from both DYNOT and CW5 systems, and are also in good agreement with the previous fNIRS study. Overall, we demonstrate that the fNIRS-based RSFC is reproducible by various DOT imaging systems among different research groups, enhancing the confidence of neuroscience researchers and clinicians to utilize fNIRS for future applications.

Paper Details

Date Published: 1 April 2011
PDF: 6 pages
J. Biomed. Opt. 16(4) 046006 doi: 10.1117/1.3561687
Published in: Journal of Biomedical Optics Volume 16, Issue 4
Show Author Affiliations
Haijing Niu, Beijing Normal Univ. (China)
Chun-Ming Lu, Beijing Normal Univ. (China)
Chaozhe Zhu, Beijing Normal Univ. (China)
Sabin Khadka, The Univ. of Texas at Arlington (United States)
Fenghua Tian, The Univ. of Texas at Arlington (United States)
Zi-Jing Lin, The Univ. of Texas at Arlington (United States)
Hanli Liu, The Univ. of Texas at Arlington (United States)

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