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Journal of Biomedical Optics

Dark-field illuminated reflectance fiber bundle endoscopic microscope
Author(s): Xuan Liu; Yong Huang; Jin Ung Kang
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Paper Abstract

We propose a reflectance fiber bundle microscope using a dark-field illumination configuration for applications in endoscopic medical imaging and diagnostics. Our experiment results show that dark-field illumination can effectively suppress strong specular reflection from the proximal end of the fiber bundle. We realized a lateral resolution of 4.4 μm using the dark-field illuminated fiber bundle configuration. To demonstrate the feasibility of using the system to study cell morphology, we obtained still and video images of two thyroid cancer cell lines. Our results clearly allow differentiation of different cancer cell types.

Paper Details

Date Published: 1 April 2011
PDF: 8 pages
J. Biomed. Opt. 16(4) 046003 doi: 10.1117/1.3560298
Published in: Journal of Biomedical Optics Volume 16, Issue 4
Show Author Affiliations
Xuan Liu, The Johns Hopkins Univ. (United States)
Yong Huang, The Johns Hopkins Univ. (United States)
Jin Ung Kang, The Johns Hopkins Univ. (United States)

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