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Journal of Biomedical Optics • Open Access

In situ imaging of lung alveoli with an optical coherence tomography needle probe
Author(s): Bryden C. Quirk; Robert A. McLaughlin; Andrea Curatolo; Rodney W. Kirk; David Douglas Sampson; Peter B. Noble

Paper Abstract

In situ imaging of alveoli and the smaller airways with optical coherence tomography (OCT) has significant potential in the assessment of lung disease. We present a minimally invasive imaging technique utilizing an OCT needle probe. The side-facing needle probe comprises miniaturized focusing optics consisting of no-core and GRIN fiber encased within a 23-gauge needle. 3D-OCT volumetric data sets were acquired by rotating and retracting the probe during imaging. The probe was used to image an intact, fresh (not fixed) sheep lung filled with normal saline, and the results validated against a histological gold standard. We present the first published images of alveoli acquired with an OCT needle probe and demonstrate the potential of this technique to visualize other anatomical features such as bifurcations of the bronchioles.

Paper Details

Date Published: 1 March 2011
PDF: 5 pages
J. Biomed. Opt. 16(3) 036009 doi: 10.1117/1.3556719
Published in: Journal of Biomedical Optics Volume 16, Issue 3
Show Author Affiliations
Bryden C. Quirk, The Univ. of Western Australia (Australia)
Robert A. McLaughlin, The Univ. of Western Australia (Australia)
Andrea Curatolo, The Univ. of Western Australia (Australia)
Rodney W. Kirk, The Univ. of Western Australia (Australia)
David Douglas Sampson, The Univ. of Western Australia (Australia)
Peter B. Noble, The Univ. of Western Australia (Australia)

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