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Journal of Biomedical Optics

Segmental analysis of indocyanine green pharmacokinetics for the reliable diagnosis of functional vascular insufficiency
Author(s): Yujung Kang; Jungsul Lee; Yuri An; Chulhee Choi; Jongwook Jeon
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Paper Abstract

Accurate and reliable diagnosis of functional insufficiency of peripheral vasculature is essential since Raynaud phenomenon (RP), most common form of peripheral vascular insufficiency, is commonly associated with systemic vascular disorders. We have previously demonstrated that dynamic imaging of near-infrared fluorophore indocyanine green (ICG) can be a noninvasive and sensitive tool to measure tissue perfusion. In the present study, we demonstrated that combined analysis of multiple parameters, especially onset time and modified Tmax which means the time from onset of ICG fluorescence to Tmax, can be used as a reliable diagnostic tool for RP. To validate the method, we performed the conventional thermographic analysis combined with cold challenge and rewarming along with ICG dynamic imaging and segmental analysis. A case-control analysis demonstrated that segmental pattern of ICG dynamics in both hands was significantly different between normal and RP case, suggesting the possibility of clinical application of this novel method for the convenient and reliable diagnosis of RP.

Paper Details

Date Published: 1 March 2011
PDF: 4 pages
J. Biomed. Opt. 16(3) 030504 doi: 10.1117/1.3556718
Published in: Journal of Biomedical Optics Volume 16, Issue 3
Show Author Affiliations
Yujung Kang, KAIST (Korea, Republic of)
Jungsul Lee, KAIST (Korea, Republic of)
Yuri An, KAIST (Korea, Republic of)
Chulhee Choi, KAIST (Korea, Republic of)
Jongwook Jeon, KAIST (Korea, Republic of)


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