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Journal of Micro/Nanolithography, MEMS, and MOEMS

Formation of polymer microneedle arrays using soft lithography
Author(s): Yoshimichi Ami; Hiroto Tachikawa; Naoki Takano; Norihisa Miki
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Paper Abstract

We demonstrate the fabrication of polymer microneedle arrays using soft lithography. A photomask was designed to use Fresnel diffraction of UV light to create sharp, tapered hollows in SU-8, a negative photoresist, after development. Polymer microneedles were formed using these SU-8 structures as a mold. These polymer needles may be applicable as flexible electrodes in brain-machine interfaces because they are more likely to survive movement of the skin than conventional brittle silicon needles. Similar needles, made from medicinal substances, could be used for transdermal drug administration. For these applications, the needles must be long, sharp, and stiff enough to penetrate the stratum corneum (∼20 μm in thickness) and reach the viable epidermis (200-300 μm in thickness), but must not reach the dermis, which contains sensitive nerve endings. We successfully manufactured 20×20 microneedle arrays of polydimethylsiloxane with a needle length of 200 μm. We experimentally verified that these manufactured electrodes successfully penetrated the stratum corneum of a cultured skin.

Paper Details

Date Published: 1 January 2011
PDF: 6 pages
J. Micro/Nanolith. MEMS MOEMS 10(1) 011503 doi: 10.1117/1.3553393
Published in: Journal of Micro/Nanolithography, MEMS, and MOEMS Volume 10, Issue 1
Show Author Affiliations
Yoshimichi Ami, Keio Univ. (Japan)
Hiroto Tachikawa, Keio Univ. (Japan)
Naoki Takano, Keio Univ. (Japan)
Norihisa Miki, Keio Univ. (Japan)

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