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Journal of Biomedical Optics • Open Access

Mathematical model that describes the transition from thermal to photochemical damage in retinal pigment epithelial cell culture
Author(s): Clifton D. Clark; Michael L. Denton; Robert J. Thomas

Paper Abstract

We propose a rate process model for describing photochemical damage to retinal cells by short wavelength laser exposures. The rate equation for photochemical damage contains a positive rate that is temperature independent, and a negative (quenching) rate that is temperature dependent. Using the traditional Arrhenius integral to describe thermal damage, we derive damage threshold doses for both thermal and photochemical mechanisms, and show that the model accounts for the sharp transition from thermal to photochemical damage thresholds that have recently been observed in an in-vitro retinal model.

Paper Details

Date Published: 1 February 2011
PDF: 3 pages
J. Biomed. Opt. 16(2) 020504 doi: 10.1117/1.3544504
Published in: Journal of Biomedical Optics Volume 16, Issue 2
Show Author Affiliations
Clifton D. Clark, TASC, Inc. (United States)
Michael L. Denton, TASC, Inc. (United States)
Robert J. Thomas, Air Force Research Lab. (United States)


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