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Journal of Biomedical Optics • Open Access

In vivo photoacoustic imaging of osteosarcoma in a rat model
Author(s): Jun Hu; Menglei Yu; Fei Ye; Da Xing

Paper Abstract

Osteosarcoma is one of the most common primary malignant tumors of the bone and the second leading cause of cancer-related deaths in the pediatric age group. Confirmed diagnosis and prompt treatment of osteosarcoma are critical for effective prognosis. In this study, we investigate the application of photoacoustic imaging (PAI) for the detection of osteosarcoma in an animal model. Cross-section images of a normal rat leg and a tumorous rat leg were successfully reconstructed in vivo. Morphological changes and the development of the implanted osteosarcoma were accurately mapped with time-dependent photoacoustic images. Furthermore, we evaluate the use of gold nanorods as contrast agents for imaging osteosarcoma with PAI. This is the first study that uses PAI to detect osteosarcoma in vivo, and the results suggest that PAI has the potential clinical application for detecting osteosarcoma in the early stage.

Paper Details

Date Published: 1 February 2011
PDF: 3 pages
J. Biomed. Opt. 16(2) 020503 doi: 10.1117/1.3544502
Published in: Journal of Biomedical Optics Volume 16, Issue 2
Show Author Affiliations
Jun Hu, Shantou Univ. (China)
Menglei Yu, Shantou Univ. (China)
Fei Ye, South China Normal Univ. (China)
Da Xing, South China Normal Univ. (China)


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