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Journal of Biomedical Optics

Terahertz pulsed imaging study to assess remineralization of artificial caries lesions
Author(s): David R. Churchley; Richard J. M. Lynch; Frank Lippert; Jennifer S. O'Bryan Eder; Jesse Alton; Carlos Gonzalez-Cabezas
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Paper Abstract

We compare terahertz-pulsed imaging (TPI) with transverse microradiography (TMR) and microindentation to measure remineralization of artificial caries lesions. Lesions are formed in bovine enamel using a solution of 0.1 M lactic acid/0.2% Carbopol C907 and 50% saturated with hydroxyapatite adjusted to pH 5.0. The 20-day experimental protocol consists of four 1 min treatment periods with dentifrices containing 10, 675, 1385, and 2700 ppm fluoride, a 4-h/day acid challenge, and, for the remaining time, specimens are stored in a 50:50 pooled human/artificial saliva mixture. Each specimen is imaged at the focal point of the terahertz beam (data-point spacing = 50 μm). The time-domain data are used to calculate the refractive index volume percent profile throughout the lesion, and the differences in the integrated areas between the baseline and post-treatment profiles are used to calculate ΔΔZ(THz). In addition, the change from baseline in both the lesion depth and the intensity of the reflected pulse from the air/enamel interface is determined. Statistically significant Pearson correlation coefficients are observed between TPI and TMR/microindentation (P < 0.05). We demonstrate that TPI has potential as a research tool for hard tissue imaging.

Paper Details

Date Published: 1 February 2011
PDF: 8 pages
J. Biomed. Opt. 16(2) 026001 doi: 10.1117/1.3540277
Published in: Journal of Biomedical Optics Volume 16, Issue 2
Show Author Affiliations
David R. Churchley, GlaxoSmithKline (United Kingdom)
Richard J. M. Lynch, GlaxoSmithKline (United Kingdom)
Frank Lippert, Indiana Univ. School of Denistry (United States)
Jennifer S. O'Bryan Eder, Indiana Univ. School of Denistry (United States)
Jesse Alton, TeraView Ltd. (United Kingdom)
Carlos Gonzalez-Cabezas, Univ. of Michigan (United States)

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