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Journal of Biomedical Optics

Intravascular laser speckle imaging catheter for the mechanical evaluation of the arterial wall
Author(s): Zeinab Hajjarian; Jingqun Xi; Guillermo J. Tearney; Seemantini K. Nadkarni; Farouc A. Jaffer
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Paper Abstract

Laser speckle imaging (LSI) is a novel technique for measuring the mechanical properties of atherosclerotic plaques. In LSI, the decorrelation time constant of speckle intensity fluctuations provides an index of viscoelasticity that is closely related to plaque microstructure and composition. Here, we demonstrate for the first time, the feasibility of conducting LSI in vivo using a prototype 1.5 mm (4.5 Fr) diameter intravascular catheter. Investigation of the catheter performance using human arterial samples ex vivo shows that plaque time constants measured by the LSI catheter correlate well with those measured using a free-space bulk optics system. To demonstrate LSI in vivo, the catheter is interfaced with a portable console for intravascular evaluation in the aorta of a living rabbit. Distinct differences in arterial time constants are identified at normal aortic and stented sites in vivo with intravascular LSI.

Paper Details

Date Published: 1 February 2011
PDF: 7 pages
J. Biomed. Opt. 16(2) 026005 doi: 10.1117/1.3533322
Published in: Journal of Biomedical Optics Volume 16, Issue 2
Show Author Affiliations
Zeinab Hajjarian, Massachusetts General Hospital (United States)
Jingqun Xi, Massachusetts General Hospital (United States)
Guillermo J. Tearney, Massachusetts General Hospital (United States)
Seemantini K. Nadkarni, Massachusetts General Hospital (United States)
Farouc A. Jaffer, Massachusetts General Hospital (United States)

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