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Journal of Biomedical Optics • Open Access

Hybrid luminescent/magnetic nanostructured porous silicon particles for biomedical applications
Author(s): Alvaro Muñoz-Noval; Vanessa Sanchez-Vaquero; Vicente Torres-Costa; Darío Gallach; Miguel Manso-Silván; Josefa P. Garcia-Ruiz; Raúl J. Martín-Palma; Vicente Ferro-Llanos; Jose Javier Serrano; Francisco del Pozo

Paper Abstract

This work describes a novel process for the fabrication of hybrid nanostructured particles showing intense tunable photoluminescence and a simultaneous ferromagnetic behavior. The fabrication process involves the synthesis of nanostructured porous silicon (NPSi) by chemical anodization of crystalline silicon and subsequent in pore growth of Co nanoparticles by electrochemically-assisted infiltration. Final particles are obtained by subsequent sonication of the Co-infiltrated NPSi layers and conjugation with poly(ethylene glycol) aiming at enhancing their hydrophilic character. These particles respond to magnetic fields, emit light in the visible when excited in the UV range, and internalize into human mesenchymal stem cells with no apoptosis induction. Furthermore, cytotoxicity in in-vitro systems confirms their biocompatibility and the viability of the cells after incorporation of the particles. The hybrid nanostructured particles might represent powerful research tools as cellular trackers or in cellular therapy since they allow combining two or more properties into a single particle.

Paper Details

Date Published: 1 February 2011
PDF: 8 pages
J. Biomed. Opt. 16(2) 025002 doi: 10.1117/1.3533321
Published in: Journal of Biomedical Optics Volume 16, Issue 2
Show Author Affiliations
Alvaro Muñoz-Noval, Univ. Autónoma de Madrid (Spain)
Vanessa Sanchez-Vaquero, Univ. Autónoma de Madrid (Spain)
Vicente Torres-Costa, Univ. Autónoma de Madrid (Spain)
Darío Gallach, Univ. Autónoma de Madrid (Spain)
Miguel Manso-Silván, Univ. Autónoma de Madrid (Spain)
Josefa P. Garcia-Ruiz, Univ. Autónoma de Madrid (Spain)
Raúl J. Martín-Palma, Univ. Autónoma de Madrid (Spain)
Vicente Ferro-Llanos, Univ. Politécnica de Madrid (Spain)
Jose Javier Serrano, Univ. Politécnica de Madrid (Spain)
Francisco del Pozo, Univ. Politécnica de Madrid (Spain)


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