Share Email Print

Journal of Biomedical Optics • Open Access

Biological reactivity of nanoparticles: mosaics from optical microscopy videos of giant lipid vesicles
Author(s): Jernej Zupanc; Andrej Dobnikar; Damjana Drobne; Janez Valant; Deniz Erdogmus; Erhan Bas

Paper Abstract

Emerging fields such as nanomedicine and nanotoxicology, demand new information on the effects of nanoparticles on biological membranes and lipid vesicles are suitable as an experimental model for bio-nano interaction studies. This paper describes image processing algorithms which stitch video sequences into mosaics and recording the shapes of thousands of lipid vesicles, which were used to assess the effect of CoFe2O4 nanoparticles on the population of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylcholine lipid vesicles. The applicability of this methodology for assessing the potential of engineered nanoparticles to affect morphological properties of lipid membranes is discussed.

Paper Details

Date Published: 1 February 2011
PDF: 10 pages
J. Biomed. Opt. 16(2) 026003 doi: 10.1117/1.3533319
Published in: Journal of Biomedical Optics Volume 16, Issue 2
Show Author Affiliations
Jernej Zupanc, Univ. of Ljubljana (Slovenia)
Andrej Dobnikar, Univ. of Ljubljana (Slovenia)
Damjana Drobne, Univ. of Ljubljana (Slovenia)
Janez Valant, Univ. of Ljubljana (Slovenia)
Deniz Erdogmus, Northeastern Univ. (United States)
Erhan Bas, Northeastern Univ. (United States)

© SPIE. Terms of Use
Back to Top