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Journal of Biomedical Optics

Improving sensitivity in nonlinear Raman microspectroscopy imaging and sensing
Author(s): Rajan Arora; Georgi I. Petrov; Vladislav V. Yakovlev; Jian Liu
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Paper Abstract

Nonlinear Raman microspectroscopy based on a broadband coherent anti-Stokes Raman scattering is an emerging technique for noninvasive, chemically specific, microscopic analysis of tissues and large population of cells and particles. The sensitivity of this imaging is a critical aspect of a number of the proposed biomedical application. It is shown that the incident laser power is the major parameter controlling this sensitivity. By careful optimizing the laser system, the high-quality vibrational spectra acquisition at the multi-kHz rate becomes feasible.

Paper Details

Date Published: 1 February 2011
PDF: 11 pages
J. Biomed. Opt. 16(2) 021114 doi: 10.1117/1.3533317
Published in: Journal of Biomedical Optics Volume 16, Issue 2
Show Author Affiliations
Rajan Arora, Univ. of Wisconsin-Milwaukee (United States)
Georgi I. Petrov, Univ. of Wisconsin-Milwaukee (United States)
Vladislav V. Yakovlev, Univ. of Wisconsin-Milwaukee (United States)
Jian Liu, PolarOnyx, Inc. (United States)

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