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Journal of Biomedical Optics • Open Access

Stent-induced coronary artery stenosis characterized by multimodal nonlinear optical microscopy
Author(s): Han-Wei Wang; Ji-Xin Cheng; Michael Sturek; Vlad V. Simianu; Matthew J. Locker

Paper Abstract

We demonstrate for the first time the applicability of multimodal nonlinear optical (NLO) microscopy to the interrogation of stented coronary arteries under different diet and stent deployment conditions. Bare metal stents and Taxus drug-eluting stents (DES) were placed in coronary arteries of Ossabaw pigs of control and atherogenic diet groups. Multimodal NLO imaging was performed to inspect changes in arterial structures and compositions after stenting. Sum frequency generation, one of the multimodalities, was used for the quantitative analysis of collagen content in the peristent and in-stent artery segments of both pig groups. Atherogenic diet increased lipid and collagen in peristent segments. In-stent segments showed decreased collagen expression in neointima compared to media. Deployment of DES in atheromatous arteries inhibited collagen expression in the arterial media.

Paper Details

Date Published: 1 February 2011
PDF: 6 pages
J. Biomed. Opt. 16(2) 021110 doi: 10.1117/1.3533313
Published in: Journal of Biomedical Optics Volume 16, Issue 2
Show Author Affiliations
Han-Wei Wang, Purdue Univ. (United States)
Ji-Xin Cheng, Purdue Univ. (United States)
Michael Sturek, Indiana Univ.-Purdue Univ. Indianapolis (United States)
Vlad V. Simianu, Indiana Univ.-Purdue Univ. Indianapolis (United States)
Matthew J. Locker, Indiana Univ.-Purdue Univ. Indianapolis (United States)

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