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Journal of Biomedical Optics

Homogenized tissue phantoms for quantitative evaluation of subsurface fluorescence contrast
Author(s): Mathieu Roy; Anthony Kim; Farhan N. Dadani; Brian C. Wilson
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Paper Abstract

The use of phantoms comprising diluted tissue homogenates with a buried capillary containing quantum dots is demonstrated as a method to investigate the optical and biophysical factors influencing the imaging of subsurface fluorescence contrast agents. Validation of the method is demonstrated using both liquid phantoms of known optical absorption and reduced scattering and Monte Carlo computer simulations of photon transport. Conclusions regarding the optimal excitation wavelength are given and quantified with respect to the tissue optical properties. The tissue homogenate method should be of value for quantitative optimization studies relevant to, for example, endoscopic imaging.

Paper Details

Date Published: 1 January 2011
PDF: 11 pages
J. Biomed. Opt. 16(1) 016013 doi: 10.1117/1.3528646
Published in: Journal of Biomedical Optics Volume 16, Issue 1
Show Author Affiliations
Mathieu Roy, Ontario Cancer Institute (Canada)
Anthony Kim, Ontario Cancer Institute (Canada)
Farhan N. Dadani, Ontario Cancer Institute (Canada)
Brian C. Wilson, Princess Margaret Hospital (Canada)

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