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Journal of Biomedical Optics • Open Access

Light penetration in the human prostate: a whole prostate clinical study at 763 nm
Author(s): Caroline M. Moore; Charles A. Mosse; Clare Allen; Heather Payne; Mark Emberton; Stephen G. Bown

Paper Abstract

Photodynamic therapy (PDT) is being investigated as a treatment for localized prostate cancer. Photodynamic therapy uses a photosensitizing drug which is activated by a specific wavelength of light, in the presence of oxygen. The activated drug reacts with tissue oxygen to produce reactive oxygen species which are responsible for localized tissue necrosis. One of the determinants of the PDT effect is the penetration of light in the prostate. This study assesses the penetration depth of 763 nm light throughout the prostate. Eight men undergoing multiple hollow needle insertion for high dose rate brachytherapy were recruited. 763 nm light, produced by a diode laser, was delivered to the prostate using cylindrically diffusing optical fibers within the plastic needles. Light was detected at different distances from the source, using an isotropic detector within nearby needles. Penetration depth was calculated using the Boltzmann approximation to the diffusion equation. Delivery detector fiber separation was measured on computed tomography. The mean penetration depth was 0.57 cm, but there was within patient variation of a mean factor of 4.3. Further work is ongoing to assess the effect of such variability in light penetration, on the PDT effect.

Paper Details

Date Published: 1 January 2011
PDF: 12 pages
J. Biomed. Opt. 16(1) 015003 doi: 10.1117/1.3528638
Published in: Journal of Biomedical Optics Volume 16, Issue 1
Show Author Affiliations
Caroline M. Moore, Univ. College London (United Kingdom)
Charles A. Mosse, Univ. College London (United Kingdom)
Clare Allen, Univ. College Hospital (United Kingdom)
Heather Payne, Univ. College London (United Kingdom)
Mark Emberton, Univ. College London (United Kingdom)
Stephen G. Bown, Univ. College London (United Kingdom)


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