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Journal of Biomedical Optics

Intraoperative imaging of cortical cerebral perfusion by time-resolved thermography and multivariate data analysis
Author(s): Gerald Steiner; Stephan B. Sobottka; Edmund Koch; Gabriele Schackert; Matthias Kirsch
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Paper Abstract

A new approach to cortical perfusion imaging is demonstrated using high-sensitivity thermography in conjunction with multivariate statistical data analysis. Local temperature changes caused by a cold bolus are imaged and transferred to a false color image. A cold bolus of 10 ml saline at ice temperature is injected systemically via a central venous access. During the injection, a sequence of 735 thermographic images are recorded within 2 min. The recorded data cube is subjected to a principal component analysis (PCA) to select slight changes of the cortical temperature caused by the cold bolus. PCA reveals that 11 s after injection the temperature of blood vessels is shortly decreased followed by an increase to the temperature before the cold bolus is injected. We demonstrate the potential of intraoperative thermography in combination with multivariate data analysis to image cortical cerebral perfusion without any markers. We provide the first in vivo application of multivariate thermographic imaging.

Paper Details

Date Published: 1 January 2011
PDF: 6 pages
J. Biomed. Opt. 16(1) 016001 doi: 10.1117/1.3528011
Published in: Journal of Biomedical Optics Volume 16, Issue 1
Show Author Affiliations
Gerald Steiner, Universitätsklinikum Carl Gustav Carus Dresden (Germany)
Stephan B. Sobottka, Technische Univ. Dresden (Germany)
Edmund Koch, Universitätsklinikum Carl Gustav Carus Dresden (Germany)
Gabriele Schackert, Technische Univ. Dresden (Germany)
Matthias Kirsch, Technische Univ. Dresden (Germany)

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