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Journal of Biomedical Optics

Fiber-laser-based photoacoustic microscopy and melanoma cell detection
Author(s): Yu Wang; Konstantin I. Maslov; Yu Zhang; Song Hu; Lih-Mei Yang; Younan Xia; Jian Liu; Lihong V. Wang
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Paper Abstract

For broad applications in biomedical research involving functional dynamics and clinical studies, a photoacoustic microscopy system should be compact, stable, and fast. In this work, we use a fiber laser as the photoacoustic irradiation source to meet these goals. The laser system measures 45×56×13 cm3. The stability of the laser is attributed to the intrinsic optical fiber-based light amplification and output coupling. Its 50-kHz pulse repetition rate enables fast scanning or extensive signal averaging. At the laser wavelength of 1064 nm, the photoacoustic microscope still has enough sensitivity to image small blood vessels while providing high optical absorption contrast between melanin and hemoglobin. Label-free melanoma cells in flowing bovine blood are imaged in vitro, yielding measurements of both cell size and flow speed.

Paper Details

Date Published: 1 January 2011
PDF: 7 pages
J. Biomed. Opt. 16(1) 011014 doi: 10.1117/1.3525643
Published in: Journal of Biomedical Optics Volume 16, Issue 1
Show Author Affiliations
Yu Wang, Washington Univ. in St. Louis (United States)
Konstantin I. Maslov, Washington Univ. in St. Louis (United States)
Yu Zhang, Washington Univ. in St. Louis (United States)
Song Hu, Washington Univ. in St. Louis (United States)
Lih-Mei Yang, PolarOnyx, Inc. (United States)
Younan Xia, Washington Univ. in St. Louis (United States)
Jian Liu, PolarOnyx, Inc. (United States)
Lihong V. Wang, Washington Univ. in St. Louis (United States)


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