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Journal of Biomedical Optics • Open Access

Light scattering of human red blood cells during metabolic remodeling of the membrane
Author(s): YongKeun Park; Catherine A. Best-Popescu; Ramachandra R. Dasari; Gabriel Popescu

Paper Abstract

We present the light scattering properties of individual human red blood cells (RBCs). We show that both the RBC static and dynamic scattering signals are altered by adenosine 5'-triphosphate (ATP)-driven membrane metabolic remodeling. To measure the light scattering signal from individual RBCs, we use diffraction phase microscopy together with a Fourier transform light scattering technique. RBC cytosolic ATPs are both chemically and metabolically depleted, and the corresponding scattering signals are compared with the light scattering signal of normal RBCs having physiologic levels of ATP.

Paper Details

Date Published: 1 January 2011
PDF: 7 pages
J. Biomed. Opt. 16(1) 011013 doi: 10.1117/1.3524509
Published in: Journal of Biomedical Optics Volume 16, Issue 1
Show Author Affiliations
YongKeun Park, Massachusetts Institute of Technology (United States)
Catherine A. Best-Popescu, Univ. of Illinois at Urbana-Champaign (United States)
Ramachandra R. Dasari, Massachusetts Institute of Technology (United States)
Gabriel Popescu, Univ. of Illinois at Urbana-Champaign (United States)

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