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Journal of Biomedical Optics

Optical system based on time-gated, intensified charge-coupled device camera for brain imaging studies
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Paper Abstract

An imaging system for brain oxygenation based on a time-gated, intensified charge-coupled device camera was developed. It allows one to image diffusely reflected light from an investigated medium at defined time windows delayed with respect to the laser pulse. Applying a fast optomechanical switch to deliver the light at a wavelength of 780 nm to nine source fibers allowed one to acquire images in times as short as 4 s. Thus, the system can be applied in in vivo studies. The system was validated in phantom experiments, in which absorbing inclusions were localized at different depths and different lateral positions. Then, the decrease in absorption of the brain tissue related to increase in oxygenation was visualized in the motor cortex area during finger tapping by a healthy volunteer.

Paper Details

Date Published: 1 November 2010
PDF: 7 pages
J. Biomed. Opt. 15(6) 066025 doi: 10.1117/1.3523366
Published in: Journal of Biomedical Optics Volume 15, Issue 6
Show Author Affiliations
Piotr L. Sawosz, Institute of Biocybernetics and Biomedical Engineering (Poland)
Michal Kacprzak, Institute of Biocybernetics and Biomedical Engineering (Poland)
Norbert S. Zolek, Institute of Biocybernetics and Biomedical Engineering (Poland)
Wojciech Weigl, Medical Univ. of Warsaw (Poland)
Stanislaw Wojtkiewicz, Institute of Biocybernetics and Biomedical Engineering (Poland)
Roman Maniewski, Institute of Biocybernetics and Biomedical Engineering (Poland)
Adam Liebert, Institute of Biocybernetics and Biomedical Engineering (Poland)


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