Share Email Print
cover

Journal of Biomedical Optics • Open Access

Photon-cell interactive Monte Carlo model based on the geometric optics theory for photon migration in blood by incorporating both extra- and intracellular pathways
Author(s): Daisuke Sakota; Setsuo Takatani

Paper Abstract

A photon-cell interactive Monte Carlo (pciMC) that tracks photon migration in both the extra- and intracellular spaces is developed without using macroscopic scattering phase functions and anisotropy factors, as required for the conventional Monte Carlos (MCs). The interaction of photons at the plasma-cell boundary of randomly oriented 3-D biconcave red blood cells (RBCs) is modeled using the geometric optics. The pciMC incorporates different photon velocities from the extra- to intracellular space, whereas the conventional MC treats RBCs as points in the space with a constant velocity. In comparison to the experiments, the pciMC yielded the mean errors in photon migration time of 9.8±6.8 and 11.2±8.5% for suspensions of small and large RBCs (RBCsmall, RBClarge) averaged over the optically diffusing region from 2000 to 4000 μm, while the conventional random walk Monte Carlo simulation gave statistically higher mean errors of 19.0±5.8 ( p < 0.047) and 21.7±19.1% (p < 0.055), respectively. The gradients of optical density in the diffusing region yielded statistically insignificant differences between the pciMC and experiments with the mean errors between them being 1.4 and 0.9% in RBCsmall and RBClarger, respectively. The pciMC based on the geometric optics can be used to accurately predict photon migration in the optically diffusing, turbid medium.

Paper Details

Date Published: 1 November 2010
PDF: 14 pages
J. Biomed. Opt. 15(6) 065001 doi: 10.1117/1.3516722
Published in: Journal of Biomedical Optics Volume 15, Issue 6
Show Author Affiliations
Daisuke Sakota, Tokyo Medical and Dental Univ. (Japan)
Setsuo Takatani, Tokyo Medical and Dental Univ. (Japan)


© SPIE. Terms of Use
Back to Top