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Journal of Biomedical Optics

Automated classification of breast pathology using local measures of broadband reflectance
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Paper Abstract

We demonstrate that morphological features pertinent to a tissue's pathology may be ascertained from localized measures of broadband reflectance, with a mesoscopic resolution (100-μm lateral spot size) that permits scanning of an entire margin for residual disease. The technical aspects and optimization of a k-nearest neighbor classifier for automated diagnosis of pathologies are presented, and its efficacy is validated in 29 breast tissue specimens. When discriminating between benign and malignant pathologies, a sensitivity and specificity of 91 and 77% was achieved. Furthermore, detailed subtissue-type analysis was performed to consider how diverse pathologies influence scattering response and overall classification efficacy. The increased sensitivity of this technique may render it useful to guide the surgeon or pathologist where to sample pathology for microscopic assessment.

Paper Details

Date Published: 1 November 2010
PDF: 12 pages
J. Biomed. Opt. 15(6) 066019 doi: 10.1117/1.3516594
Published in: Journal of Biomedical Optics Volume 15, Issue 6
Show Author Affiliations
Ashley M. Laughney, Dartmouth College (United States)
Venkataramanan Krishnaswamy, Dartmouth College (United States)
Pilar Beatriz García-Allende, Univ. de Cantabria (United Kingdom)
Olga M. Conde, Univ. de Cantabria (Spain)
Wendy A. Wells, Dartmouth Hitchcock Medical Ctr. (United States)
Keith D. Paulsen, Dartmouth College (United States)
Brian W. Pogue, Dartmouth College (United States)


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