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Journal of Biomedical Optics

Enhancing magnetic resonance imaging tumor detection with fluorescence intensity and lifetime imaging
Author(s): Ahmet Erten; David J. Hall; Carl K. Hoh; Hop S. Tran Cao; Sharmeela Kaushal; Sadik C. Esener; Robert M. Hoffman; Michael Bouvet; James Chen; Santosh Kesari; Milan T. Makale
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Paper Abstract

Early detection is important for many solid cancers but the images provided by ultrasound, magnetic resonance imaging (MRI), and computed tomography applied alone or together, are often not sufficient for decisive early screening/diagnosis. We demonstrate that MRI augmented with fluorescence intensity (FI) substantially improves detection. Early stage murine pancreatic tumors that could not be identified by blinded, skilled observers using MRI alone, were easily identified with MRI along with FI images acquired with photomultiplier tube detection and offset laser scanning. Moreover, we show that fluorescence lifetime (FLT) imaging enables positive identification of the labeling fluorophore and discriminates it from surrounding tissue autofluorescence. Our data suggest combined-modality imaging with MRI, FI, and FLT can be used to screen and diagnose early tumors.

Paper Details

Date Published: 1 November 2010
PDF: 6 pages
J. Biomed. Opt. 15(6) 066012 doi: 10.1117/1.3509111
Published in: Journal of Biomedical Optics Volume 15, Issue 6
Show Author Affiliations
Ahmet Erten, Univ. of California, San Diego (United States)
David J. Hall, Univ. of California, San Diego (United States)
Carl K. Hoh, Univ. of California, San Diego (United States)
Hop S. Tran Cao, Univ. of California, San Diego (United States)
Sharmeela Kaushal, Univ. of California, San Diego (United States)
Sadik C. Esener, Univ. of California, San Diego (United States)
Robert M. Hoffman, AntiCancer, Inc. (United States)
Michael Bouvet, Univ. of California, San Diego (United States)
James Chen, Univ. of California, San Diego (United States)
Santosh Kesari, Univ. of California, San Diego (United States)
Milan T. Makale, Univ. of California, San Diego (United States)


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