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Journal of Biomedical Optics • Open Access

Noninvasive assessment of breast cancer risk using time-resolved diffuse optical spectroscopy
Author(s): Paola Taroni; Antonio Pifferi; Giovanna Quarto; Lorenzo Spinelli; Alessandro Torricelli; Francesca Abbate; Anna M. Villa; Nicola Balestreri; Simona Menna; Enrico Cassano; Rinaldo Cubeddu

Paper Abstract

Breast density is a recognized strong and independent risk factor for breast cancer. We propose the use of time-resolved transmittance spectroscopy to estimate breast tissue density and potentially provide even more direct information on breast cancer risk. Time-resolved optical mammography at seven wavelengths (635 to 1060 nm) is performed on 49 subjects. Average information on breast tissue of each subject is obtained on oxy- and deoxyhemoglobin, water, lipids, and collagen content, as well as scattering amplitude and power. All parameters, except for blood volume and oxygenation, correlate with mammographic breast density, even if not to the same extent. A synthetic optical index proves to be quite effective in separating different breast density categories. Finally, the estimate of collagen content as a more direct means for the assessment of breast cancer risk is discussed.

Paper Details

Date Published: 1 November 2010
PDF: 3 pages
J. Biomed. Opt. 15(6) 060501 doi: 10.1117/1.3506043
Published in: Journal of Biomedical Optics Volume 15, Issue 6
Show Author Affiliations
Paola Taroni, Politecnico di Milano (Italy)
Antonio Pifferi, Politecnico di Milano (Italy)
Giovanna Quarto, Politecnico di Milano (Italy)
Lorenzo Spinelli, Politecnico di Milano (Italy)
Alessandro Torricelli, Politecnico di Milano (Italy)
Francesca Abbate, Istituto Europeo di Oncologia (Italy)
Anna M. Villa, Istituto Europeo di Oncologia (Italy)
Nicola Balestreri, Istituto Europeo di Oncologia (Italy)
Simona Menna, Istituto Europeo di Oncologia (Italy)
Enrico Cassano, Istituto Europeo di Oncologia (Italy)
Rinaldo Cubeddu, Politecnico di Milano (Italy)

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