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Journal of Biomedical Optics

Imaging heterogeneous absorption distribution of advanced breast cancer by optical tomography
Author(s): Yan Xu; Quing Zhu
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Paper Abstract

Tumor vascular patterns of advanced breast cancers are complex and heterogeneous. Two typical light absorption patterns of periphery enhancement and posterior shadowing have been observed when imaging these advanced cancers using optical tomography guided by ultrasound. We perform a series simulation and phantom experiments to systemically evaluate the effects of target parameters, target locations, and target optical properties on imaging periphery enhancement absorption distribution using reflection geometry. Large tumors are modeled as concentric semiellipsoidal targets of different outer shell and inner core optical properties. We show that larger targets of more than 3 to 4 cm diameter with outer shell thicknesses less than 1 cm can be resolved at a depth less than 3 cm. A clinical example is given to show the complex vasculature distributions seen from an advanced cancer.

Paper Details

Date Published: 1 November 2010
PDF: 17 pages
J. Biomed. Opt. 15(6) 066007 doi: 10.1117/1.3505015
Published in: Journal of Biomedical Optics Volume 15, Issue 6
Show Author Affiliations
Yan Xu, Univ. of Connecticut (United States)
Quing Zhu, Univ. of Connecticut (United States)


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