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Journal of Biomedical Optics • Open Access

Tumor bracketing and safety margin estimation using multimodal marker seeds: a proof of concept
Author(s): Tessa Buckle; Patrick T.K. Chin; Nynke S. van den Berg; Claudette E. Loo; Wim Koops; Kenneth G. A. Gilhuijs; Fijs W.B. van Leeuwen

Paper Abstract

Accurate tumor excision is crucial in the locoregional treatment of cancer, and for this purpose, surgeons often rely on guide wires or radioactive markers for guidance toward the lesion. Further improvement may be obtained by adding optical guidance to currently used methods, in the form of intra-operative fluorescence imaging. To achieve such a multimodal approach, we have generated markers that can be used in a pre-, intra-, and post-operative setting, based on a cocktail of a dual-emissive inorganic dye, lipids, and pertechnetate. Phantom experiments demonstrate that these seeds can be placed accurately around a surrogate tumor using ultrasound. Three-dimensional bracketing provides delineation of the entire lesion. Combined with the multimodal nature, this provides the opportunity to predetermine the resection margins by validating the placement accuracy using multiple imaging modalities (namely, x ray, MRI, SPECT/CT, and ultrasound). The dual-emissive fluorescent properties of the dye provide the unique opportunity to intra-operatively estimate the depth of the seed in the tissue via multispectral imaging: emission green max=520 nm5 mm penetration versus emission red max=660 nm12 mm penetration. By using particles with different colors, the original geographic orientation of the excised tissue can be determined.

Paper Details

Date Published: 1 September 2010
PDF: 8 pages
J. Biomed. Opt. 15(5) 056021 doi: 10.1117/1.3503955
Published in: Journal of Biomedical Optics Volume 15, Issue 5
Show Author Affiliations
Tessa Buckle, The Netherlands Cancer Institute (Netherlands)
Patrick T.K. Chin, The Netherlands Cancer Institute (Netherlands)
Nynke S. van den Berg, The Netherlands Cancer Institute (Netherlands)
Claudette E. Loo, The Netherlands Cancer Institute (Netherlands)
Wim Koops, The Netherlands Cancer Institute (Netherlands)
Kenneth G. A. Gilhuijs, The Netherlands Cancer Institute (Netherlands)
Fijs W.B. van Leeuwen, The Netherlands Cancer Institute (Netherlands)


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