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Journal of Biomedical Optics

Heart wall velocimetry and exogenous contrast-based cardiac flow imaging in Drosophila melanogaster using Doppler optical coherence tomography
Author(s): Michael A. Choma; Melissa J. Suter; Benjamin J. Vakoc; Brett E. Bouma; Gary J. Tearney
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Paper Abstract

Drosophila melanogaster (fruit fly) is a central organism in biology and is becoming increasingly important in the cardiovascular sciences. Prior work in optical imaging of the D. melanogaster heart has focused on static and dynamic structural anatomy. In the study, it is demonstrated that Doppler optical coherence tomography can quantify dynamic heart wall velocity and hemolymph flow in adult D. melanogaster. Since hemolymph is optically transparent, a novel exogenous contrast technique is demonstrated to increase the backscatter-based intracardiac Doppler flow signal. The results presented here open up new possibilities for functional cardiovascular phenotyping of normal and mutant D. melanogaster.

Paper Details

Date Published: 1 September 2010
PDF: 6 pages
J. Biomed. Opt. 15(5) 056020 doi: 10.1117/1.3503418
Published in: Journal of Biomedical Optics Volume 15, Issue 5
Show Author Affiliations
Michael A. Choma, Children's Hospital Boston (United States)
Melissa J. Suter, Massachusetts General Hospital (United States)
Benjamin J. Vakoc, Massachusetts General Hospital (United States)
Brett E. Bouma, Wellman Ctr. for Photomedicine (United States)
Gary J. Tearney, Wellman Ctr. for Photomedicine (United States)

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