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Journal of Biomedical Optics • Open Access

Cancer-cell microsurgery using nonlinear optical endomicroscopy

Paper Abstract

Near-infrared laser-based microsurgery is promising for noninvasive cancer treatment. To make it a safe technique, a therapeutic process should be controllable and energy efficient, which requires the cancer cells to be identifiable and observable. In this work, for the first time we use a miniaturized nonlinear optical endomicroscope to achieve microtreatment of cancer cells labeled with gold nanorods. Due to the high two-photon-excited photoluminescence of gold nanorods, HeLa cells inside a tissue phantom up to 250 µm deep can be imaged by the nonlinear optical endomicroscope. This facilitates microsurgery of selected cancer cells by inducing instant damage through the necrosis process, or by stopping cell proliferation through the apoptosis process. The results indicate that a combination of nonlinear endomicroscopy with gold nanoparticles is potentially viable for minimally invasive cancer treatment.

Paper Details

Date Published: 1 September 2010
PDF: 3 pages
J. Biomed. Opt. 15(5) 050502 doi: 10.1117/1.3502566
Published in: Journal of Biomedical Optics Volume 15, Issue 5
Show Author Affiliations
Min Gu, Swinburne Univ. of Technology (Australia)
Hong Chun Bao, Swinburne Univ. of Technology (Australia)
Jing Liang Li, Swinburne Univ. of Technology (Australia)

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