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Journal of Biomedical Optics • Open Access

Visibility of trabecular meshwork by standard and polarization-sensitive optical coherence tomography

Paper Abstract

Polarization-sensitive optical coherence tomography (PS-OCT) is known to be advantageous because of its additional tissue-specific contrast of the anterior eye. So far, this advantage has been shown only qualitatively. We evaluate the improved visibility afforded by 3-D PS corneal and anterior eye segment OCT (PS-CAS-OCT) in visualizing the trabecular meshwork (TM) based on statistical evidences. A total of 31 normal subjects participated in this study. The anterior eye segments of both the eyes of the subjects are scanned using a custom-made PS-CAS-OCT and the standard-scattering OCT (S-OCT) and polarization-sensitive phase-retardation OCT (P-OCT) images are obtained. Three graders grade the visibility of the TM using a four-leveled grading system. The intergrader agreement, intermodality differences, and interquadrant dependence of visibility are statistically examined. All three of three combinations of graders show substantial agreement in visibility with P-OCT (ρ = 0.74, 0.70, and 0.68, Spearman's correlation), while only one of three shows substantial agreement with S-OCT (ρ = 0.72). Significant dependence of the visibility on the modality (S-OCT versus P-OCT) and quadrants are found by the analysis of variance. A subsequent Wilcoxon signed-rank test reveals significantly improved visibility. PS-CAS-OCT may become a useful tool for screening angle-closure glaucoma.

Paper Details

Date Published: 1 November 2010
PDF: 10 pages
J. Biomed. Opt. 15(6) 061705 doi: 10.1117/1.3499421
Published in: Journal of Biomedical Optics Volume 15, Issue 6
Show Author Affiliations
Yoshiaki Yasuno, Univ. of Tsukuba (Japan)
Masahiro Yamanari, Tomey Corp. (Japan)
Keisuke Kawana, Univ. of Tsukuba (Japan)
Masahiro Miura, Tokyo Medical Univ. Kasumigaura Hospital (Japan)
Shinichi Fukuda, Univ. of Tsukuba (Japan)
Shuichi Makita, Univ. of Tsukuba (Japan)
Shingo Sakai, Kanebo Cosmetics Inc. (Japan)
Tetsuro Oshika, Univ. of Tsukuba (Japan)

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