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Journal of Biomedical Optics • Open Access

Segmentation and quantification of retinal lesions in age-related macular degeneration using polarization-sensitive optical coherence tomography
Author(s): Bernhard Baumann; Erich Götzinger; Michael Pircher; Harald Sattmann; Christopher Schütze; Ferdinand Schlanitz; Christian Ahlers; Ursula Schmidt-Erfurth; Christoph K. Hitzenberger

Paper Abstract

We present polarization-sensitive optical coherence tomography (PS-OCT) for quantitative assessment of retinal pathologies in age-related macular degeneration (AMD). On the basis of the polarization scrambling characteristics of the retinal pigment epithelium, novel segmentation algorithms were developed that allow one to segment pathologic features such as drusen and atrophic zones in dry AMD as well as to determine their dimensions. Results from measurements in the eyes of AMD patients prove the ability of PS-OCT for quantitative imaging based on the retinal features polarizing properties. Repeatability measurements were performed in retinas diagnosed with drusen and geographic atrophy in order to evaluate the performance of the described methods. PS-OCT appears as a promising imaging modality for three-dimensional retinal imaging and ranging with additional contrast based on the structures' tissue-inherent polarization properties.

Paper Details

Date Published: 1 November 2010
PDF: 9 pages
J. Biomed. Opt. 15(6) 061704 doi: 10.1117/1.3499420
Published in: Journal of Biomedical Optics Volume 15, Issue 6
Show Author Affiliations
Bernhard Baumann, Medizinische Univ. Wien (Austria)
Erich Götzinger, Medizinische Univ. Wien (Austria)
Michael Pircher, Medizinische Univ. Wien (Austria)
Harald Sattmann, Medizinische Univ. Wien (Austria)
Christopher Schütze, Medizinische Univ. Wien (Austria)
Ferdinand Schlanitz, Medizinische Univ. Wien (Austria)
Christian Ahlers, Medizinische Univ. Wien (Austria)
Ursula Schmidt-Erfurth, Medizinische Univ. Wien (Austria)
Christoph K. Hitzenberger, Medizinische Univ. Wien (Austria)

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