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Journal of Biomedical Optics • Open Access

Image guided near-infrared spectroscopy of breast tissue in vivo using boundary element method
Author(s): Subhadra Srinivasan; Colin M. Carpenter; Hamid R. Ghadyani; Senate J. Taka; Peter A. Kaufman; Roberta M. diFlorio-Alexander; Wendy A. Wells; Brian W. Pogue; Keith D. Paulsen

Paper Abstract

We demonstrate quantitative functional imaging using image-guided near-infrared spectroscopy (IG-NIRS) implemented with the boundary element method (BEM) for reconstructing 3-D optical property estimates in breast tissue in vivo. A multimodality MRI-NIR system was used to collect measurements of light reflectance from breast tissue. The BEM was used to model light propagation in 3-D based only on surface discretization in order to reconstruct quantitative values of total hemoglobin (HbT), oxygen saturation, water, and scatter. The technique was validated in experimental measurements from heterogeneous breast-shaped phantoms with known values and applied to a total of seven subjects comprising six healthy individuals and one participant with cancer imaged at two time points during neoadjuvant chemotherapy. Using experimental measurements from a heterogeneous breast phantom, BEM for IG-NIRS produced accurate values for HbT in the inclusion with a <3% error. Healthy breast tissues showed higher HbT and water in fibroglandular tissue than in adipose tissue. In a subject with cancer, the tumor showed higher HbT compared to the background. HbT in the tumor was reduced by 9 µM during treatment. We conclude that 3-D MRI-NIRS with BEM provides quantitative and functional characterization of breast tissue in vivo through measurement of hemoglobin content. The method provides potentially complementary information to DCE-MRI for tumor characterization.

Paper Details

Date Published: 1 November 2010
PDF: 8 pages
J. Biomed. Opt. 15(6) 061703 doi: 10.1117/1.3499419
Published in: Journal of Biomedical Optics Volume 15, Issue 6
Show Author Affiliations
Subhadra Srinivasan, Dartmouth College (United States)
Colin M. Carpenter, Stanford Univ. School of Medicine (United States)
Hamid R. Ghadyani, Dartmouth College (United States)
Senate J. Taka, Dartmouth College (United States)
Peter A. Kaufman, Dartmouth Hitchcock Medical Ctr. (United States)
Roberta M. diFlorio-Alexander, Dartmouth Hitchcock Medical Ctr. (United States)
Wendy A. Wells, Dartmouth Hitchcock Medical Ctr. (United States)
Brian W. Pogue, Dartmouth College (United States)
Keith D. Paulsen, Dartmouth College (United States)

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