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Journal of Biomedical Optics • Open Access

System for interstitial photodynamic therapy with online dosimetry: first clinical experiences of prostate cancer
Author(s): Johannes Swartling; Johan Axelsson; Göran Ahlgren; Karl Mikael Kälkner; Sten Nilsson; Sune Svanberg; Katarina Svanberg; Stefan Andersson-Engels

Paper Abstract

The first results from a clinical study for Temoporfin-mediated photodynamic therapy (PDT) of low-grade (T1c) primary prostate cancer using online dosimetry are presented. Dosimetric feedback in real time was applied, for the first time to our knowledge, in interstitial photodynamic therapy. The dosimetry software IDOSE provided dose plans, including optical fiber positions and light doses based on 3-D tissue models generated from ultrasound images. Tissue optical property measurements were obtained using the same fibers used for light delivery. Measurements were taken before, during, and after the treatment session. On the basis of these real-time measured optical properties, the light-dose plan was recalculated. The aim of the treatment was to ablate the entire prostate while minimizing exposure to surrounding organs. The results indicate that online dosimetry based on real-time tissue optical property measurements enabled the light dose to be adapted and optimized. However, histopathological analysis of tissue biopsies taken six months post-PDT treatment showed there were still residual viable cancer cells present in the prostate tissue sections. The authors propose that the incomplete treatment of the prostate tissue could be due to a too low light threshold dose, which was set to 5 J/cm2.

Paper Details

Date Published: 1 September 2010
PDF: 9 pages
J. Biomed. Opt. 15(5) 058003 doi: 10.1117/1.3495720
Published in: Journal of Biomedical Optics Volume 15, Issue 5
Show Author Affiliations
Johannes Swartling, SpectraCure AB (Sweden)
Johan Axelsson, Lund Univ. (Sweden)
Göran Ahlgren, Malmö Univ. Hospital (Sweden)
Karl Mikael Kälkner, Karolinska Univ. Hospital (Sweden)
Sten Nilsson, Karolinska Univ. Hospital (Sweden)
Sune Svanberg, Lund Univ. (Sweden)
Katarina Svanberg, Lund Univ. Hospital (Sweden)
Stefan Andersson-Engels, Lund Univ. (Sweden)


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