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Journal of Biomedical Optics

Cancer detection by native fluorescence of urine
Author(s): Vadivel Masilamani; Vijmasi Trinka; Mohammad Al Salhi; Kanagaraj Govindaraj; Ayanam Parthasarathy Vijaya Raghavan; Belavendra Antonisamy
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Paper Abstract

Because cancer is a dreaded disease, a number of techniques such as biomarker evaluation, mammograms, colposcopy, and computed tomography scan are currently employed for early diagnosis. Many of these are specific to a particular site, invasive, and often expensive. Hence, there is a definite need for a simple, generic, noninvasive protocol for cancer detection, comparable to blood and urine tests for diabetes. Our objective is to show the results of a novel study in the diagnosis of several cancer types from the native or intrinsic fluorescence of urine. We use fluorescence emission spectra (FES) and stokes shift spectra (SSS) to analyze the native fluorescence of the first voided urine samples of healthy controls (N=100) and those of cancer patients (N=50) of different etiology. We show that flavoproteins and porphyrins released into urine can act as generic biomarkers of cancer with a specificity of 92%, a sensitivity of 76%, and an overall accuracy of 86.7%. We employ FES and SSS for rapid and cost-effective quantification of certain intrinsic biomarkers in urine for screening and diagnosis of most common cancer types with an overall accuracy of 86.7%.

Paper Details

Date Published: 1 September 2010
PDF: 9 pages
J. Biomed. Opt. 15(5) 057003 doi: 10.1117/1.3486553
Published in: Journal of Biomedical Optics Volume 15, Issue 5
Show Author Affiliations
Vadivel Masilamani, King Saud Univ. (Saudi Arabia)
Vijmasi Trinka, Thendrel Inc. (United States)
Mohammad Al Salhi, King Saud Univ. (Saudi Arabia)
Kanagaraj Govindaraj
Ayanam Parthasarathy Vijaya Raghavan, King Saud Univ. (Saudi Arabia)
Belavendra Antonisamy, King Saud Univ. (Saudi Arabia)

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