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Journal of Biomedical Optics

Identification of source of calcium in HeLa cells by femtosecond laser excitation
Author(s): Hao He; Siu-Kai Kong; Kam Tai Chan
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Paper Abstract

Calcium is an important messenger in cells and whose store and diffusion dynamics at the subcellular level remain unclear. By inducing a controlled slow subcellular Ca2+ release through femtosecond laser irradiation in HeLa cells immersed in different media, cytoplasm is identified to be the major intracellular Ca2+ store, with the nucleus being the minor store and the extracellular Ca2+ also contributing to the total cellular Ca2+ level. Furthermore, Ca2+ released in either the cytoplasm or nucleus diffuses into the nucleus or cytoplasm, respectively, at different rates and influences the Ca2+ release in those regions.

Paper Details

Date Published: 1 September 2010
PDF: 5 pages
J. Biomed. Opt. 15(5) 057010 doi: 10.1117/1.3485741
Published in: Journal of Biomedical Optics Volume 15, Issue 5
Show Author Affiliations
Hao He, The Chinese Univ. of Hong Kong (Hong Kong, China)
Siu-Kai Kong, The Chinese Univ. of Hong Kong (Hong Kong, China)
Kam Tai Chan, The Chinese Univ. of Hong Kong (Hong Kong, China)


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