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Journal of Biomedical Optics • Open Access

Parametric imaging of cancer with optical coherence tomography
Author(s): Robert A. McLaughlin; Loretta Scolaro; Peter Robbins; Christobel Saunders; Steven L. Jacques; David D. Sampson

Paper Abstract

We present a parametric optical coherence tomography (OCT) technique to improve contrast between malignant and healthy non-neoplastic tissue. The technique incorporates a fully automated method to extract tissue attenuation characteristics. Results are represented visually as a parametric en face image, where the parameter used for contrast is indicative of the relative optical attenuation coefficient of the tissue. We present the first parametric OCT images of human lymph nodes containing malignant cells, and demonstrate improved tissue contrast over en face OCT images.

Paper Details

Date Published: 1 July 2010
PDF: 4 pages
J. Biomed. Opt. 15(4) 046029 doi: 10.1117/1.3479931
Published in: Journal of Biomedical Optics Volume 15, Issue 4
Show Author Affiliations
Robert A. McLaughlin, The Univ. of Western Australia (Australia)
Loretta Scolaro, The Univ. of Western Australia (Australia)
Peter Robbins, PathWest Lab. Medicine WA (Australia)
Christobel Saunders, The Univ. of Western Australia (Australia)
Steven L. Jacques, Oregon Health & Science Univ. (United States)
David D. Sampson, The Univ. of Western Australia (Australia)

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