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Journal of Biomedical Optics

Growth of melanoma brain tumors monitored by photoacoustic microscopy
Author(s): Jacob Staley; Patrick Grogan; Abbas K. Samadi; Huizhong Cui; Mark S. Cohen; Xinmai Yang
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Paper Abstract

Melanoma is a primary malignancy that is known to metastasize to the brain and often causes death. The ability to image the growth of brain melanoma in vivo can provide new insights into its evolution and response to therapies. In our study, we use a reflection mode photoacoustic microscopy (PAM) system to detect the growth of melanoma brain tumor in a small animal model. The melanoma tumor cells are implanted in the brain of a mouse at the beginning of the test. Then, PAM is used to scan the region of implantation in the mouse brain, and the growth of the melanoma is monitored until the death of the animal. It is demonstrated that PAM is capable of detecting and monitoring the brain melanoma growth noninvasively in vivo.

Paper Details

PDF: 3 pages
J. Biomed. Opt. 15(4) 040510 doi: 10.1117/1.3478309
Published in: Journal of Biomedical Optics Volume 15, Issue 4, July 2010
Show Author Affiliations
Jacob Staley, The Univ. of Kansas (United States)
Patrick Grogan, The Univ. of Kansas Medical Ctr. (United States)
Abbas K. Samadi, The Univ. of Kansas Medical Ctr. (United States)
Huizhong Cui, The Univ. of Kansas (United States)
Mark S. Cohen, The Univ. of Kansas Medical Ctr. (United States)
Xinmai Yang, The Univ. of Kansas (United States)

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