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Journal of Biomedical Optics

Intravascular optical coherence tomography on a beating heart model
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Paper Abstract

The advantages and limitations of using a beating heart model in the development of intravascular optical coherence tomography are discussed. The model fills the gap between bench experiments, performed on phantoms and excised arteries, and whole animal in-vivo preparations. The beating heart model is stable for many hours, allowing for extended measurement times and multiple imaging sessions under in-vivo conditions without the complications of maintaining whole-animal preparation. The perfusate supplying the heart with nutrients can be switched between light scattering blood to a nonscattering perfusate to allow the optical system to be optimized without the need of an efficient blood displacement strategy. Direct access to the coronary vessels means that there is no need for x-ray fluoroscopic guidance of the catheter to the heart, as is the case in whole animal preparation. The model proves to be a valuable asset in the development of our intravascular optical coherence tomography technology.

Paper Details

Date Published: 1 July 2010
PDF: 7 pages
J. Biomed. Opt. 15(4) 046023 doi: 10.1117/1.3475960
Published in: Journal of Biomedical Optics Volume 15, Issue 4
Show Author Affiliations
Guy Lamouche, National Research Council Canada (Canada)
Marc L. Dufour, National Research Council Canada (Canada)
Mark D. Hewko, National Research Council Canada (Canada)
Sébastien Vergnole, National Research Council Canada (Canada)
Bruno Gauthier, National Research Council Canada (Canada)
Charles-Etienne Bisaillon, National Research Council Canada (Canada)
Jean-Pierre Monchalin, National Research Council Canada (Canada)
Michael G. Sowa, National Research Council Canada (Canada)

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