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Journal of Biomedical Optics • Open Access

Combined optical coherence tomography and electroretinography system for in vivo simultaneous morphological and functional imaging of the rodent retina
Author(s): Alireza Akhlagh Moayed; Sepideh Hariri; Chulho Hyun; Bruce Doran; Timothy W. Kraft; Shelley Boyd; Kostadinka K. Bizheva

Paper Abstract

A combined ultrahigh resolution optical coherence tomography (UHROCT) and a electroretinography (ERG) system is presented for simultaneous imaging of the retinal structure and physiological response to light stimulation in the rodent eye. The 1060-nm UHROCT system provides ~3×5 µm (axial×lateral) resolution in the rat retina and time resolution of 22 µs. A custom-designed light stimulator integrated into the UHROCT imaging probe provides light stimuli with user-selected color, duration, and intensity. The performance of the combined system is demonstrated in vivo in healthy rats, and in a rat model of drug-induced outer retinal degeneration. Experimental results show correlation between the observed structural and physiological changes in the healthy and degenerated retina.

Paper Details

Date Published: 1 July 2010
PDF: 3 pages
J. Biomed. Opt. 15(4) 040506 doi: 10.1117/1.3475489
Published in: Journal of Biomedical Optics Volume 15, Issue 4
Show Author Affiliations
Alireza Akhlagh Moayed, Univ. of Waterloo (Canada)
Sepideh Hariri, Univ. of Waterloo (Canada)
Chulho Hyun, Univ. of Waterloo (Canada)
Bruce Doran, Diagnosys, LLC (United States)
Timothy W. Kraft, The Univ. of Alabama at Birmingham (United States)
Shelley Boyd, St. Michael's Hospital (Canada)
Kostadinka K. Bizheva, Univ. of Waterloo (Canada)

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