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Journal of Biomedical Optics

Handheld array-based photoacoustic probe for guiding needle biopsy of sentinel lymph nodes
Author(s): Chulhong Kim; Todd N. Erpelding; Konstantin I. Maslov; Ladislav Jankovic; Walter J. Akers; Liang Song; Samuel Achilefu; Julie A. Margenthaler; Michael D. Pashley; Lihong V. Wang
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Paper Abstract

By modifying a clinical ultrasound array system, we develop a novel handheld photoacoustic probe for image-guided needle biopsy. The integration of optical fiber bundles for pulsed laser light delivery enables photoacoustic image-guided insertion of a needle into rat axillary lymph nodes with accumulated indocyanine green (ICG). Strong photoacoustic contrast of the needle is achieved. After subcutaneous injection of the dye in the left forepaw, sentinel lymph nodes are easily detected, in vivo and in real time, beneath 2-cm-thick chicken breast overlaying the axillary region. ICG uptake in axillary lymph nodes is confirmed with fluorescence imaging both in vivo and ex vivo. These results demonstrate the clinical potential of this handheld photoacoustic system for facile identification and needle biopsy of sentinel lymph nodes for cancer staging and metastasis detection in humans.

Paper Details

PDF: 4 pages
J. Biomed. Opt. 15(4) 046010 doi: 10.1117/1.3469829
Published in: Journal of Biomedical Optics Volume 15, Issue 4, July 2010
Show Author Affiliations
Chulhong Kim, Washington Univ. in St. Louis (United States)
Pohang Univ. of Science and Technology (Korea, Republic of)
Todd N. Erpelding, Philips Research North America (United States)
Konstantin I. Maslov, Washington Univ. in St. Louis (United States)
Ladislav Jankovic, Philips Research North America (United States)
Walter J. Akers, Washington Univ. in St. Louis (United States)
Washington Univ. School of Medicine in St. Louis (United States)
Liang Song, Washington Univ. in St. Louis (United States)
Shenzhen Institute of Advanced Technology (China)
Samuel Achilefu, Washington Univ. in St. Louis (United States)
Washington Univ. School of Medicine in St. Louis (United States)
Julie A. Margenthaler, Washington Univ. in St. Louis (United States)
Washington Univ. School of Medicine in St. Louis (United States)
Michael D. Pashley, Philips Research North America (United States)
Lihong V. Wang, Washington Univ. in St. Louis (United States)


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