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Journal of Biomedical Optics

Study of back-scattering microspectrum for stomach cells at single-cell scale
Author(s): Cheng Wang; Xudong Guo; Baoying Fang; Chengli Song
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Paper Abstract

A fiber confocal backscattering (FCBS) spectrometer is developed based on fiber confocal microscopy and light scattering theory. The FCBS spectrometer can provide imaging and spectral information simultaneously at the cellular scale. Normal stomach epithelial cell line GES-1 and cancerous cell line NCI-N87 are measured and their spectral results show that backscattering intensity from NCI-N87 cells is stronger than that from GES-1 cells in 500 to 800 nm, and the GES-1 cells scattering spectra show regular intensity changes, while the NCI-N87 cells do not. The experiments prove that the FCBS spectrometer is able to distinguish cancerous cells from normal stomach cells at the cellular level. The spectrometer could be further developed into a noninvasive optical technology for early cancer detection.

Paper Details

Date Published: 1 July 2010
PDF: 3 pages
J. Biomed. Opt. 15(4) 040505 doi: 10.1117/1.3469782
Published in: Journal of Biomedical Optics Volume 15, Issue 4
Show Author Affiliations
Cheng Wang, Univ. of Shanghai for Science and Technology (China)
Xudong Guo, Univ. of Shanghai for Science and Technology (China)
Baoying Fang, Univ. of Shanghai for Science and Technology (China)
Chengli Song, Univ. of Shanghai for Science and Technology (China)

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