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Journal of Biomedical Optics

Photodynamic therapy: superficial and interstitial illumination
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Paper Abstract

Photodynamic therapy (PDT) is reviewed using the treatment of skin tumors as an example of superficial lesions and prostate cancer as an example of deep-lying lesions requiring interstitial intervention. These two applications are among the most commonly studied in oncological PDT, and illustrate well the different challenges facing the two modalities of PDT-superficial and interstitial. They thus serve as good examples to illustrate the entire field of PDT in oncology. PDT is discussed based on the Lund University group's over 20 yr of experience in the field. In particular, the interplay between optical diagnostics and dosimetry and the delivery of the therapeutic light dose are highlighted. An interactive multiple-fiber interstitial procedure to deliver the required therapeutic dose based on the assessment of light fluence rate and sensitizer concentration and oxygen level throughout the tumor is presented.

Paper Details

Date Published: 1 July 2010
PDF: 10 pages
J. Biomed. Opt. 15(4) 041502 doi: 10.1117/1.3466579
Published in: Journal of Biomedical Optics Volume 15, Issue 4
Show Author Affiliations
Katarina Svanberg, Lund Univ. Hospital (Sweden)
Niels Bendsoe, Lund Univ. Hospital (Sweden)
Johan Axelsson, Lund Univ. (Sweden)
Stefan Andersson-Engels, Lund Univ. (Sweden)
Sune Svanberg, Lund Univ. (Sweden)

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