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Journal of Biomedical Optics

Highly reproducible swept-source, dispersion-encoded full-range biometry and imaging of the mouse eye
Author(s): Ling Wang; Bernd Hofer; Yen-Po Chen; Jeremy A. Guggenheim; Wolfgang Drexler; Boris Považay
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Paper Abstract

We report a high-speed, dispersion-encoded, full-range (DEFR) swept-source optical coherence tomography system for in vivo ocular imaging and biometry of small animals. The fast DEFR algorithm removes the depth ambiguity, gives access to objects located at the zero delay position, and doubles the sampling depth to 2×5.0 mm (at −101 to −71 dB sensitivity) in a single scan using 2048 samples/depth scan 0.43 nm line width of a light source operating at 1056 nm with 70 nm tuning range. The acquisition speed (frames of 512 depth scans in 18.3 ms) permits precise on-line monitoring during positioning and provides cross-sectional views of the mouse eye. Preliminary studies demonstrate high-throughput, reproducible assessment of multiple biometric features (e.g., day-to-day reproducibility of axial length measurement ±5.3 µm) that is insensitive to eye motion sufficient for long-term monitoring.

Paper Details

Date Published: 1 July 2010
PDF: 6 pages
J. Biomed. Opt. 15(4) 046004 doi: 10.1117/1.3463480
Published in: Journal of Biomedical Optics Volume 15, Issue 4
Show Author Affiliations
Ling Wang, Cardiff Univ. (United Kingdom)
Bernd Hofer, Medizinische Univ. Wien (Austria)
Yen-Po Chen, Cardiff Univ. (United Kingdom)
Jeremy A. Guggenheim, Cardiff Univ. (United Kingdom)
Wolfgang Drexler, Medizinische Univ. Wien (Austria)
Boris Považay, Cardiff Univ. (United Kingdom)


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