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Journal of Biomedical Optics

Changes of collagen and nicotinamide adenine dinucleotide in human cancerous and normal prostate tissues studied using native fluorescence spectroscopy with selective excitation wavelength
Author(s): Yang Pu; Wubao Wang; G. C. Tang; Robert R. Alfano
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Paper Abstract

The fluorescence spectra of human cancerous and normal prostate tissues obtained by the selective excitation wavelength of 340 nm were measured. The contributions of principle biochemical components to tissue fluorescence spectra were investigated using the method of multivariate curve resolution with alternating least squares. The results show that there is a reduced contribution from the emission of collagen and increased contribution from nicotinamide adenine dinucleotide (NADH) in cancerous tissues as compared with normal tissue. This difference is attributed to the changes of relative contents of NADH and collagen during cancer development. This research may present a potential native biomarker for prostate cancer detection.

Paper Details

Date Published: 1 July 2010
PDF: 5 pages
J. Biomed. Opt. 15(4) 047008 doi: 10.1117/1.3463479
Published in: Journal of Biomedical Optics Volume 15, Issue 4
Show Author Affiliations
Yang Pu, The City College of New York (United States)
Wubao Wang, The City College of New York (United States)
G. C. Tang, The City College of New York (United States)
Robert R. Alfano, The City College of New York (United States)


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