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Journal of Biomedical Optics • Open Access

In vivo functional retinal optical coherence tomography
Author(s): Tilman Schmoll; Christoph Kolbitsch; Rainer A. Leitgeb

Paper Abstract

An experimental design for noninvasive assessment of neural retinal tissue function with enhanced sensitivity is presented. By matching the response detection to a defined flicker frequency stimulus similar to heterodyne detection, the response signal will be shifted out of the low-frequency noise and the specificity of response detection will be strongly enhanced. Optimal measurement parameters are discussed, such as the function and timing of the response function to a single flash stimulus. The results indicate responses on the order of 200 ms that have been probed with our frequency-encoded approach using 5 Hz flickering. Preliminary results indicate the feasibility of our measurement concept to assess small changes in reflectivity with enhanced sensitivity. A functional tomogram for response localization and quantification is introduced.

Paper Details

Date Published: 1 July 2010
PDF: 8 pages
J. Biomed. Opt. 15(4) 041513 doi: 10.1117/1.3463008
Published in: Journal of Biomedical Optics Volume 15, Issue 4
Show Author Affiliations
Tilman Schmoll, Medizinische Univ. Wien (Austria)
Christoph Kolbitsch, Medizinische Univ. Wien (Austria)
Rainer A. Leitgeb, Medizinische Univ. Wien (Austria)

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