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Journal of Biomedical Optics

In-vivo dynamic characterization of microneedle skin penetration using optical coherence tomography
Author(s): Joey G. Enfield; Marie-Louise O'Connell; Kate Lawlor; Enock Jonathan; Conor O'Mahony; Martin J. Leahy
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Paper Abstract

The use of microneedles as a method of circumventing the barrier properties of the stratum corneum is receiving much attention. Although skin disruption technologies and subsequent transdermal diffusion rates are being extensively studied, no accurate data on depth and closure kinetics of microneedle-induced skin pores are available, primarily due to the cumbersome techniques currently required for skin analysis. We report on the first use of optical coherence tomography technology to image microneedle penetration in real time and in vivo. We show that optical coherence tomography (OCT) can be used to painlessly measure stratum corneum and epidermis thickness, as well as microneedle penetration depth after microneedle insertion. Since OCT is a real-time, in-vivo, nondestructive technique, we also analyze skin healing characteristics and present quantitative data on micropore closure rate. Two locations (the volar forearm and dorsal aspect of the fingertip) have been assessed as suitable candidates for microneedle administration. The results illustrate the applicability of OCT analysis as a tool for microneedle-related skin characterization.

Paper Details

Date Published: 1 July 2010
PDF: 7 pages
J. Biomed. Opt. 15(4) 046001 doi: 10.1117/1.3463002
Published in: Journal of Biomedical Optics Volume 15, Issue 4
Show Author Affiliations
Joey G. Enfield, Univ. of Limerick (Ireland)
Marie-Louise O'Connell, Univ. of Limerick (Ireland)
Kate Lawlor, Univ. of Limerick (Ireland)
Enock Jonathan, Univ. of Limerick (Ireland)
Conor O'Mahony, Tyndall National Institute (Ireland)
Martin J. Leahy, Univ. of Limerick (Ireland)

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