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Journal of Biomedical Optics

Comprehensive investigation of three-dimensional diffuse optical tomography with depth compensation algorithm
Author(s): Haijing Niu; Zijing Lin; Fenghua Tian; Sameer Dhamne; Hanli Liu
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Paper Abstract

A depth compensation algorithm (DCA) can effectively improve the depth localization of diffuse optical tomography (DOT) by compensating the exponentially decreased sensitivity in the deep tissue. In this study, DCA is investigated based on computer simulations, tissue phantom experiments, and human brain imaging. The simulations show that DCA can largely improve the spatial resolution of DOT in addition to the depth localization, and DCA is also effective for multispectral DOT with a wide range of optical properties in the background tissue. The laboratory phantom experiment demonstrates that DCA can effectively differentiate two embedded objects at different depths in the medium. DCA is further validated by human brain imaging using a finger-tapping task. To our knowledge, this is the first demonstration to show that DCA is capable of accurately localizing cortical activations in the human brain in three dimensions.

Paper Details

Date Published: 1 July 2010
PDF: 9 pages
J. Biomed. Opt. 15(4) 046005 doi: 10.1117/1.3462986
Published in: Journal of Biomedical Optics Volume 15, Issue 4
Show Author Affiliations
Haijing Niu, The Univ. of Texas at Arlington (United States)
Zijing Lin, The Univ. of Texas at Arlington (United States)
Fenghua Tian, The Univ. of Texas at Arlington (United States)
Sameer Dhamne, The Univ. of Texas at Arlington (United States)
Hanli Liu, The Univ. of Texas at Arlington (United States)

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