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Journal of Biomedical Optics • Open Access

Detection of Plasmodium falciparum-infected red blood cells by optical stretching
Author(s): Jakob M. A. Mauritz; Teresa Tiffert; Rachel Seear; Franziska Lautenschlaeger; Alessandro Esposito; Virgilio L. Lew; Jochen R. Guck; Clemens F. Kaminski

Paper Abstract

We present the application of a microfluidic optical cell stretcher to measure the elasticity of malaria-infected red blood cells. The measurements confirm an increase in host cell rigidity during the maturation of the parasite Plasmodium falciparum. The device combines the selectivity and sensitivity of single-cell elasticity measurements with a throughput that is higher than conventional single-cell techniques. The method has potential to detect early stages of infection with excellent sensitivity and high speed.

Paper Details

Date Published: 1 May 2010
PDF: 3 pages
J. Biomed. Opt. 15(3) 030517 doi: 10.1117/1.3458919
Published in: Journal of Biomedical Optics Volume 15, Issue 3
Show Author Affiliations
Jakob M. A. Mauritz, Univ. of Cambridge (United Kingdom)
Teresa Tiffert, Univ. of Cambridge (United Kingdom)
Rachel Seear, Univ. of Cambridge (United Kingdom)
Franziska Lautenschlaeger, Univ. of Cambridge (United Kingdom)
Alessandro Esposito, Univ. of Cambridge (United Kingdom)
Virgilio L. Lew, Univ. of Cambridge (United Kingdom)
Jochen R. Guck, Univ. of Cambridge (United Kingdom)
Clemens F. Kaminski, Univ. of Cambridge (United Kingdom)

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